近年来,巨大儿发生率逐年增多。巨大儿会增加剖宫产、肩难产和臂丛神经损伤等不良分娩结局的发生风险,远期还会使儿童超重和肥胖等风险增加。巨大儿的发生与遗传因素、孕龄过长、营养过剩、代谢异常等有关,但具体作用机制仍不清楚。研究发现,脂肪组织能够合成分泌多种脂肪因子,如瘦素、抵抗素、网膜素、内脂素、视黄醇结合蛋白4、脂联素等,不仅参与调控代谢、神经内分泌、免疫等功能活 In recent years, the incidence of huge children increased year by year. Giant children will increase the incidence of cesarean section, shoulder dystocia and brachial plexus injury and other adverse delivery outcomes, the long-term will make children overweight and obesity and other risks increased. The occurrence of giant children and genetic factors, gestational age is too long, excess nutrients, metabolic abnormalities and other related, but the specific mechanism of action is still not clear. The study found that adipose tissue can synthesize and secrete a variety of adipokines, such as leptin, resistin, retinal, visfatin, retinol binding protein 4, adiponectin, etc., not only involved in the regulation of metabolism, neuroendocrine, immune Function live