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目的研究乳腺特异基因BCSG1(SNCG)和Ki-67在胃癌组织中的表达及意义。方法采用免疫组化法观察60例胃癌(A组)及20例正常胃黏膜石蜡(C组)标本中SNCG和Ki-67蛋白的表达。结果 A组SNCG和Ki-67的阳性表达率分别为65.0%和73.3%,均显著高于C组的0和20.0%(P<0.01)。SNCG和Ki-67的表达与胃癌的浸润深度、淋巴结转移及肿瘤临床分期密切相关(P<0.05或P<0.01)。且SNCG的表达和Ki-67的表达呈正相关(P<0.01)。结论 SNCG和Ki-67在胃癌组织中显著高表达,与胃癌的浸润转移相关,可能共同参与胃癌的发生、发展过程。
Objective To study the expression and significance of breast specific genes BCSG1 (SNCG) and Ki-67 in gastric cancer. Methods The expressions of SNCG and Ki-67 in 60 cases of gastric cancer (group A) and 20 cases of normal gastric mucosa paraffin (group C) were observed by immunohistochemistry. Results The positive rates of SNCG and Ki-67 in group A were 65.0% and 73.3%, respectively, which were significantly higher than those in group C (0 and 20.0%, P <0.01). The expressions of SNCG and Ki-67 were closely related to the depth of invasion, lymph node metastasis and clinical stage (P <0.05 or P <0.01). The expression of SNCG was positively correlated with the expression of Ki-67 (P <0.01). Conclusions The expression of SNCG and Ki-67 in gastric cancer tissues is significantly high, which is correlated with the infiltration and metastasis of gastric cancer and may be involved in the occurrence and development of gastric cancer.