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目的探讨合并糖尿病对于高血压病患者血浆P-选择素水平和颈动脉内膜中层厚度的影响。方法 120例高血压病患者分为高血压合并糖尿病组(A组,46例)和单纯高血压组(B组,74例),另选择健康体检者30例作为对照(C组)。测定三组血浆P-选择素、空腹血糖、血脂和颈动脉内膜中层厚度。结果与C组相比,A、B两组的血浆P-选择素水平和颈动脉内膜中层厚度均升高(P<0.01),而A组的血浆P-选择素水平和颈动脉内膜中层厚度又高于B组(P<0.01)。低密度脂蛋白胆固醇、空腹血糖和血浆P-选择素是颈动脉硬化的危险因素。结论合并糖尿病的高血压病患者血浆P-选择素水平升高,是高血压病患者颈动脉硬化的危险因素。
Objective To investigate the effect of diabetes mellitus on plasma P-selectin and carotid artery intima-media thickness in patients with essential hypertension. Methods One hundred and twenty patients with hypertension were divided into hypertension group (group A, n = 46) and hypertension group (group B, n = 74). Another 30 healthy subjects were selected as control group (group C). Plasma P-selectin, fasting plasma glucose, lipids and carotid intima-media thickness were measured in three groups. Results Compared with group C, plasma P-selectin levels and carotid artery intima-media thickness were significantly increased in groups A and B (P <0.01), while plasma P-selectin levels in group A were significantly lower than those in carotid intima Middle thickness was higher than the B group (P <0.01). Low-density lipoprotein cholesterol, fasting plasma glucose and plasma P-selectin are risk factors for carotid atherosclerosis. Conclusions Plasma P-selectin levels are elevated in hypertensive patients with diabetes mellitus, which is a risk factor for carotid atherosclerosis in hypertensive patients.