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近年来在抗癌药方面发展起来的微囊剂型,虽然生物利用度和长效方面都有增加,但并不能提高抗癌药本身的选择毒性作用。为了弥补这一缺陷,作者以下述方法赋与微囊以强磁性,然后由体外磁场把它诱入癌病灶并使之固定在病灶区,以充分发挥其对癌细胞的选择毒性的效果。具体制备方法:乙基纤维素1g,聚乙二醇0.5g 分散于100ml 的环己烷中,搅拌,加热至全溶,加入丝裂霉素 C 粉(MMC)2g,室温静置后,MMC 即被微囊化,除去产生相分离的聚乙二醇和环己烷后,再加入100ml 含有0.5g 铁酸盐磁粉(Fe_(80)Zn_(20)·Fe_2O_3,
In recent years, the development of anti-cancer drugs in microcapsules formulations, although the bioavailability and long-term aspects have increased, but it does not improve the selective toxicity of anticancer drugs itself. In order to remedy this defect, the authors impart ferromagnetic properties to the microcapsules in the following manner, which are then induced by an extracorporeal magnetic field into the cancerous lesion and fixed in the lesion area to fully exert their selective toxicity on cancer cells. Specific preparation method: ethyl cellulose 1g, polyethylene glycol 0.5g dispersed in 100ml of cyclohexane, stirred, heated to full dissolution, added mitomycin C powder (MMC) 2g, after standing at room temperature, MMC That is microencapsulated to remove the phase separation of polyethylene glycol and cyclohexane, then add 100ml containing 0.5g ferrite magnetic powder (Fe_ (80) Zn_ (20) Fe_2O_3,