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抗生素相关性出血性结肠炎(antibiotics—associated hemorrhagic colitis,AHC)是抗生素相关性结肠炎(antibiot—ics—associated colitis,AAC)的一种独特类型,该类型肠炎中艰难梭菌培养及毒素检测均阴性。与艰难梭菌所引起的AAC不同的是,AHC在停用抗生素后能够自愈。目前AHC的病原菌尚不明确,本研究提示为产酸克雷伯菌。作者等研究22例AAC患者,均接受结肠镜检查,并对其粪标本进行艰难梭菌、空肠弯曲杆菌、沙门菌、耶尔森菌、志贺菌属、大肠埃希菌O157、产酸克雷伯菌培养并检测艰难梭菌毒素A。同时对385例健康志愿者的粪便进行产酸克雷伯菌培养及细胞毒素检测,采用E试验测定药敏。
Antibiotics-associated hemorrhagic colitis (AHC) is a unique type of antibiotic-associated colitis (AAC). Both C. difficile culture and toxin detection in this type of enteritis negative. Unlike AAC caused by Clostridium difficile, AHC is able to heal itself after discontinuing antibiotics. At present, the pathogen of AHC is not yet clear, the present study suggests that Klebsiella oxytoca. The authors studied 22 patients with AAC who underwent colonoscopy and tested for C. difficile, Campylobacter jejuni, Salmonella, Yersinia, Shigella, Escherichia coli O157, Legionella pneumoniae Clostridium difficile toxin A was cultured and tested. At the same time, 385 healthy volunteers’ stools were tested for the production of Klebsiella oxytoca and their cytotoxicity. Drug susceptibility was determined by E test.