探讨ET在先兆早产发病过程中的作用。用放射免疫法测定 30例先兆早产妇女和 2 8例同孕周正常妊娠妇女 ,30例足月孕临产后潜伏期妇女 ,2 5例正常非孕期妇女外周血浆中内皮素 - 1(ET - 1)含量。妊娠妇女血浆ET - 1显著高于正常非孕组 ,先兆早产组、潜伏期组显著高于正常孕周组 ,先兆早产组与潜伏期组无显著差异。提示 :ET - 1可能在分娩发动中起着重要的作用 ,先兆早产可能与孕妇血浆ET - 1水平增高有关。 To explore the role of ET in the pathogenesis of threatened preterm labor. The levels of plasma endothelin - 1 (ET - 1) in peripheral blood were measured by radioimmunoassay in 30 women with threatened preterm labor and 28 normal pregnant women with gestational age, 30 pregnant women with full term pregnancy after childbirth, and 25 normal nonpregnant women. content. The plasma levels of ET - 1 in pregnant women were significantly higher than those in normal nonpregnant group, the threatened preterm birth group, the latency group were significantly higher than those in normal gestational age group, and those in preterm preterm birth group and latency group were not significantly different. It is suggested that ET - 1 may play an important role in the onset of labor, and threatened preterm labor may be related to the increase of ET - 1 in pregnant women.