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目的探讨盐酸拓扑替康联合顺铂治疗上皮性卵巢癌的疗效及毒副反应。方法将手术后经病理检查确诊为Ⅱ～Ⅳ期上皮性卵巢癌的68例患者按入选时间顺序分为2组:治疗组与对照组,每组34例。治疗组给予顺铂90 mg/m2,静脉滴注,d1;盐酸拓扑替康0.8 mg/m2,d1～5。对照组给予顺铂90 mg/m2静脉滴注,d1;环磷酰胺800 mg/m2静脉注射,d1。2组患者均以20 d为1疗程。5～7个疗程后评价疗效。结果临床疗效:治疗组完全缓解10例,部分缓解16例,有效率为76.5%;对照组完全缓解5例,部分缓解14例,有效率为55.8%。治疗组与对照组有效率比较差异有统计学意义(P<0.05)。毒副反应:发生Ⅲ～Ⅳ度骨髓抑制的患者,治疗组16例(47.1%),对照组为13例(38.2%),2组毒副反应发生率差异无统计学意义(P>0.05)。结论盐酸拓扑替康联合顺铂是治疗上皮性卵巢癌的有效方案,临床疗效较好,安全性高,其不良反应可控制,患者可耐受。
Objective To investigate the curative effect and toxicity of topotecan hydrochloride combined with cisplatin in the treatment of epithelial ovarian cancer. Methods Sixty-eight patients diagnosed with stage Ⅱ-Ⅳ epithelial ovarian cancer by pathology were divided into two groups according to the selected time sequence: the treatment group and the control group, with 34 cases in each group. The treatment group was given cisplatin 90 mg / m2, intravenous infusion, d1; topotecan hydrochloride 0.8 mg / m2, d1 ~ 5. The control group was given cisplatin 90 mg / m2 intravenous drip, d1; cyclophosphamide 800 mg / m2 intravenous injection, d1.2 patients were treated with a course of 20 d. After 5 to 7 courses evaluate the curative effect. Results The clinical curative effect: The treatment group completely relieved 10 cases, partially relieved 16 cases, the effective rate was 76.5%; the control group completely relieved 5 cases, partially relieved 14 cases, the effective rate was 55.8%. There was significant difference between the treatment group and the control group (P <0.05). Toxicity and side effects: There were 16 cases (47.1%) in the treated group and 13 (38.2%) in the control group. There was no significant difference in the incidence of side effects between the two groups (P> 0.05) . Conclusion Topotecan hydrochloride combined with cisplatin is an effective treatment for epithelial ovarian cancer. The curative effect is good, the safety is high, the adverse reactions can be controlled and the patients can tolerate it.