【摘 要】
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Somatic mutations(SMs)accumulate over the lifetime of cells and can lead to cancer and other diseases;however,SMs can be difficult to detect,especially when they are present in very few cells.In a recent Nature paper,Abascal et al.develop a protocol capab
【机 构】
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Department of Biomedical Informatics,Harvard Medical School,Boston,MA,USA
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Somatic mutations(SMs)accumulate over the lifetime of cells and can lead to cancer and other diseases;however,SMs can be difficult to detect,especially when they are present in very few cells.In a recent Nature paper,Abascal et al.develop a protocol capable of detecting SMs present on only a single molecule of DNA and apply it to both mitotic and post-mitotic human tissues.
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