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目的比较前列地尔与法舒地尔治疗急性脑梗死的临床疗效。方法选取2013年1月—2015年7月榆林市第一医院收治的急性脑梗死患者92例,随机分为对照组(44例)和治疗组(48例)。对照组静脉滴注盐酸法舒地尔注射液,60 mg加入到生理盐水250 m L中,1次/d。治疗组静脉滴注前列地尔注射液,20μg加入到生理盐水250 m L中,1次/d。两组患者均连续治疗2周。观察两组的临床疗效,比较两组NISS评分、正五聚体蛋白3(PTX-3)及颈动脉粥样斑块的变化。结果治疗后,对照组和治疗组的总有效率分别为77.3%、93.8%,两组比较差异有统计学意义(P<0.05)。治疗后,两组NISS评分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组NISS评分的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组PTX-3均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组PTX-3的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组斑块形成率显著下降,而稳定斑块比例上升,治疗组同组治疗前后比较差异有统计学意义(P<0.05)。对照组和治疗组斑块形成率分别为35.4%、56.8%,稳定斑块所占比例分别为52.0%、94.1%,两组比较差异具有统计学意义(P<0.05)。结论前列地尔治疗急性脑梗死具有较好的临床疗效,可改善临床症状,降低PTX-3,提高斑块稳定性,安全性较好,具有一定的临床推广应用价值。
Objective To compare the clinical efficacy of alprostadil and fasudil in the treatment of acute cerebral infarction. Methods From January 2013 to July 2015, 92 patients with acute cerebral infarction admitted to Yulin First Hospital were randomly divided into control group (44 cases) and treatment group (48 cases). Control group intravenous fasudil hydrochloride injection, 60 mg was added to normal saline 250 m L, 1 / d. The treatment group intravenous alprostadil injection, 20μg added to normal saline 250 m L, 1 / d. Two groups of patients were treated for 2 weeks. The clinical efficacy of the two groups was observed. The NISS score, pentagonal protein 3 (PTX-3) and carotid artery plaque were compared between the two groups. Results After treatment, the total effective rate of the control group and the treatment group were 77.3% and 93.8%, respectively, with significant difference between the two groups (P <0.05). After treatment, the scores of NISS in both groups were significantly lower than those in the control group (P <0.05), and the reduction of NISS score in the treatment group was significantly better than that in the control group (P <0.05). The difference between the two groups was statistically significant P <0.05). After treatment, the two groups of PTX-3 were significantly reduced compared with the same group before and after treatment was statistically significant (P <0.05); and the treatment group decreased PTX-3 was significantly better than the control group, the difference between the two groups was statistically significant Significance (P <0.05). After treatment, the plaque formation rate of both groups decreased significantly, while the proportion of stable plaques increased. The difference between the two groups was statistically significant (P <0.05). The rate of plaque formation in the control group and the treatment group were 35.4% and 56.8%, respectively, and the percentage of stable plaques was 52.0% and 94.1% respectively. There was significant difference between the two groups (P <0.05). Conclusion Alprostadil treatment of acute cerebral infarction has good clinical efficacy, can improve clinical symptoms, reduce PTX-3, improve plaque stability, safety is good, with a certain clinical application value.