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本文应用荧光偏振免疫分析法测定了家兔肌注安定前或1周后静注笨妥因钠的血药浓度,计算其药代动力学参数。结果表明,安定能明显影响兔体内苯妥因钠的药代功力学。12h时两组血药浓度相差非常显著,给安定后苯妥因钠的t_(1/2)明显延长,药代动力学模型由原来一室开放模型变为二室开放模型,而AUC和清除率无明显改变。
Fluorescence polarization immunoassay was used to determine the pharmacokinetic parameters of sodium stupid for sodium injection before or 1 week after intramuscular injection of prazosin. The results show that diazepam can significantly affect the pharmacokinetics of phenytoin sodium in rabbits. 12h when the difference between the two groups of plasma concentrations was very significant to diazepam phenothiazine t_ (1/2) significantly prolonged pharmacokinetic model from the original open-chamber model into a two-compartment open model, and AUC and clear No significant change in rates.