Background: The mechanisms behind motor recovery from stroke are not clearly understood. Functional imaging studies have demonstrated task related brain activation in several motor areas, but few studies have attempted to correlate this with stroke outcome. Moreover, these studies have focused on how motor areas may individually contribute to compensation. Here, the authors investigate whether different cortical areas interact to form dynamic assemblies that may then compensate for disability. Metho ds: The authors investigated corticocortical coherence in 16 healthy subjects and 25 patients with chronic stroke involving one cerebral hemisphere and having varying degrees of motor recovery. Scalp EEG was recorded at rest and while right handed subjects performed a unimanual grip task. The degree of functional recovery after stroke was assessed using a range of outcome measures. Results: Compared with healthy subjects, hand related asymmetries in task related EEG EEG coherence were increased between mesial and lateral frontal regions of the affected hemisphere, over mesial frontal regions, and over lateral frontal areas of the unaffected hemisphere when patients with stroke gripped with their affected hand. Mesial hand related asymmetries in task related power and coherence were negatively correlated with recovery. Conclusion: Increases in task related coupling between cortical areas may dynamically compensate for brain damage after stroke. Some of this increased coupling, particularly that over mesial frontal areas, decreases as patients make a functional recovery. Background: The mechanisms behind motor recovery from stroke are not clearly understood. Functional imaging studies have demonstrated task related brain activation in several motor areas, but few studies have attempted to correlate this with stroke outcome. Moreover, these studies have focused on how motor areas may individually contribute to compensation. Here, the authors investigate whether different cortical areas interact to form dynamic assemblies that may then compensate for disability. Metho ds: The authors investigated corticocortical coherence in 16 healthy subjects and 25 patients with chronic stroke involving one cerebral hemisphere and Having degrees of motor recovery. Scalp EEG was recorded at rest and while right handed subjects performed a unimanual grip task. The degree of functional recovery after stroke was assessed using a range of outcome measures. Results: Compared with healthy subjects, hand related differencestries in task related EEG EEG coherence were incre ased between mesial and lateral frontal regions of the affected hemisphere, over mesial frontal regions, and over lateral frontal areas of the unaffected hemisphere when patients with stroke gripped with their affected hand. Mesial hand related asymmetries in task related power and coherence were negatively correlated with recovery. Conclusion: Increases in task related coupling between cortical areas may dynamically compensate for brain damage after stroke. Some of this increased coupling, particularly that over mesial frontal areas, decreases as patients make a functional recovery.