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目的探讨不同组织淋巴结外恶性淋巴瘤(extranodal malignant lymphoma,ELA)的临床病理特点。方法结合临床资料,采用组织形态及免疫组织化学相结合的方法,对脾、乳腺、扁桃体、皮肤、甲状腺、脑组织的6例病理诊断为淋巴结外恶性淋巴瘤(ELA)的病例进行临床、病理分析。结果发生在不同部位的淋巴结外恶性淋巴瘤(ELA)临床表现缺乏特异性,与相应部位的癌相似。组织学形态与低分化癌难以鉴别,但通过仔细观察及免疫组织化学可以正确做出诊断。结论不同部位淋巴结外恶性淋巴瘤(ELA)组织形态学具有独特的组织像,易与其他肿瘤混淆,造成误诊、漏诊,应引起临床及病理医师的高度重视。
Objective To investigate the clinicopathological features of extranodal malignant lymphoma (ELA) in different tissues. Methods Six cases of pathologically diagnosed lymph node outside malignant lymphoma (ELA) with spleen, breast, tonsil, skin, thyroid and brain tissues were selected according to clinical data and histomorphology and immunohistochemistry. The clinical, pathological analysis. Results The clinical manifestations of extra-lymph node malignant lymphoma (ELA) occurred in different parts of the lack of specificity, and the corresponding part of the cancer. Histological morphology and poorly differentiated carcinoma is difficult to identify, but by careful observation and immunohistochemistry can make a correct diagnosis. Conclusion The histological features of different lymphoid malignant lymphoma (ELA) at different sites have unique histological features, which are easily confused with other tumors, resulting in misdiagnosis and missed diagnosis, which should attract the attention of clinicians and pathologists.