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目的:探讨血小板功能在急性白血病治疗前和缓解后的变化及其意义。方法:对65例急性白血病患者治疗前和缓解后进行了血小板功能的测定,同时52名正常献血者作为对照。血小板黏附试验(PAdT)采用玻珠柱法。血小板聚集试验(PAgT)采用比浊法。结果:患者治疗前和治疗达完全缓解后血小板黏附、ADP聚集功能,差异均有显著性(P<0.05);患者治疗前与正常对照血小板功能差异有显著性(P<0.05);而达完全缓解后血小板功能与正常对照差异无显著性(P>0.05)。结论:急性白血病治疗前血小板黏附、聚集功能明显降低,而缓解后血小板功能恢复正常,因此,在急性白血病治疗中测定血小板功能可预测治疗效果。
Objective: To investigate the changes and their significance of platelet function before and after the treatment of acute leukemia. Methods: The platelet function was measured in 65 patients with acute leukemia before and after remission. At the same time, 52 normal blood donors were used as control. Platelet adhesion test (PAdT) using glass beads column method. Platelet aggregation test (PAgT) using the turbidimetric method. Results: There was significant difference in platelet adhesion and ADP aggregation before and after complete remission (P <0.05). There was a significant difference in platelet function before and after treatment (P <0.05) Platelet function after remission was no significant difference with normal control (P> 0.05). CONCLUSION: Platelet adhesion and aggregation before acute leukemia are significantly reduced, while platelet function is restored to normal after acute leukemia treatment. Therefore, the determination of platelet function in the treatment of acute leukemia can predict the therapeutic effect.