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目的 测定有脑中风家族史儿童血清脂蛋白(a)[LP(a)] 水平,探讨脑中风与儿童的关系。方法 采用酶联免端吸附试验方法(ELISA 法)对34 例有脑中风家族史的儿童检测血清LP(a) 水平,并与30 例正常儿童对照比较。结果 有脑中风家族史儿童的血清LP(a) 水平明显高于对照组P< 0.01),一、二级亲属间比较,LP(a)水平无明显差异P> 0.05) ,LP(a)与apoB成正相关。有脑中风家族史儿童血清LP(a) 明显增高。结论 LP(a)可作为有脑中风家族史儿童的筛查指标,早期干预,以期降低有脑中风家族史儿童日后发生脑中风的危险性。
Objective To determine the level of serum lipoprotein (a) [LP (a)] in children with a family history of stroke and explore the relationship between stroke and children. Methods Serum LP (a) levels were measured in 34 children with a family history of stroke by enzyme linked immunosorbent assay (ELISA) and compared with 30 normal children. Results The level of LP (a) in the children with a history of stroke was significantly higher than that in the control group (P <0.01). There was no significant difference in LP (a) between the first and second degree relatives (P> 0.05) (A) Positive correlation with apoB. Serum LP (a) was significantly higher in children with a family history of stroke. Conclusions LP (a) can be used as a screening index for children with a family history of stroke with early intervention in order to reduce the risk of future stroke in children with a family history of stroke.