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从沼泽绿蛙的皮肤中经提取、分离得到蛙皮活性提取物（ＲＧＡＥ），分高、低剂量（０．４５ｇ／ｋｇ，０．２２ｇ／ｋｇ）灌胃给予高血脂小鼠一周。结果显示能明显降低高血脂症小鼠血清和肝脏的甘油三酯含量，与高血脂对照组相比，分别降低２１．６％和１８．９％；４５．６％和３６．８％，高剂量组还使血清和肝脏的总胆固醇含量分别比对照组降低２６．８％和１３．８％。明显降低血清低密度脂蛋白的量，比对照组降低４０．９％，可提高血清高密度脂蛋白与胆固醇的值，比对照组提高３３．３％。ＲＧＡＥ还可明显减轻四氯化碳所致肝损伤，小鼠血清谷丙转氨酶活力高剂量组比对照组降低２９．１％。
From the skin of swamp green frog, Raga active extract (RGAE) was isolated and divided into high and low dose (0.45g / kg, 0.22g / kg) gavage for one week. The results showed that the levels of triglyceride in serum and liver of mice with hyperlipidemia were significantly decreased by 21.6% and 18.9% compared with hyperlipemia control group respectively; 45.6% and 36.8% respectively The dose group also reduced the total cholesterol levels in serum and liver by 26.8% and 13.8%, respectively, over the control group. Significantly reduce the amount of serum low-density lipoprotein, 40.9% lower than the control group, can increase the value of serum high-density lipoprotein and cholesterol, 33.3% higher than the control group. RGAE can also significantly reduce liver damage caused by carbon tetrachloride, mice serum alanine aminotransferase activity of high-dose group compared with the control group decreased 29.1%.