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Pelger(1928)首先于荷兰描述一例患者血液中白细胞核分叶减少,以中性粒细胞为最突出,大部分为杆状核及2叶核,3叶者甚罕见。以后Huet调查证明此异常情况具有家族性,以非性相连之显性方式遗传,但无病理意义。嗣后世界各地相继报告,分布甚广,并沿用“Pelger氏(或Pelger-Huet)白细胞异常”之名称。其发生率在德国约为1/1020,英国约1/6000,美国约1/4785。另一报告美国之发生率约为1/10000。至于我国人之发生情况,早在1935
Pelger (1928) first described in the Netherlands a patient’s blood leukocyte nucleus decreased, the most prominent neutrophils, mostly rod-like nucleus and 2 leaf core, 3 leaves are rare. After the Huet investigation proved that the abnormal situation has a familial, non-sexual linked to the dominant way of inheritance, but no pathological significance. Subsequently reported around the world, widely distributed, and follow the “Pelger’s (or Pelger-Huet) leukocyte abnormalities,” the name. Its incidence in Germany is about 1/1020, the United Kingdom about 1/6000, the United States about 1/4785. Another report the United States the incidence of about 1/10000. As for the occurrence of our country, as early as 1935