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目的:研究三黄散瘀巴布剂的抗炎镇痛作用。方法:制备低、中、高剂量的三黄散瘀巴布剂,观察不同剂量三黄散瘀巴布剂对二甲苯所致小鼠耳肿胀和10%蛋清所致大鼠足趾肿胀的抗炎作用;观察不同剂量三黄散瘀巴布剂对小鼠醋酸扭体和小鼠热板法的作用。结果:三黄散瘀巴布剂对10%蛋清所致大鼠足趾肿胀和二甲苯所致小鼠耳肿胀有明显的抑制作用(P<0.05);能明显减少由醋酸引起的小鼠扭体次数,可显著提高小鼠的痛阈值(P<0.05)。结论:三黄散瘀巴布剂具有较好的抗炎、镇痛作用。
Objective: To study the anti-inflammatory and analgesic effects of San-huang-huang-yu-pus preparation. Methods: Preparation of low, medium and high doses of Sanhuang bulk paste, observed different doses of Sanhuang scattered bloodsuppress on mice induced by xylene ear swelling and 10% egg white induced rat’s toe swelling Inflammatory effect; observation of different doses of Sanhuang bulk paste on mouse acetic acid writhing and mouse hot plate method. Results: Sanhuang capsule could significantly inhibit the rat’s toe swelling caused by 10% albumen and xylene-induced ear swelling in mice (P <0.05), and could significantly reduce the mice torsion induced by acetic acid Body number, can significantly increase the pain threshold in mice (P <0.05). Conclusion: Sanhuang Sanji Pusu has good anti-inflammatory and analgesic effects.