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[目的]研究6-苄氨基嘌呤合成的新方法。[方法]以醋酸酐为原料,把腺嘌呤核苷经酰化生成2’,3’,5’-三氧乙酰基腺苷,在催化剂的作用下使嘌呤碱基和五元糖中的糖苷键断裂而生成乙酰腺嘌呤,然后在相转移催化剂四丁基氟化铵作用下,和苄甲醇反应生产6-苄氨基腺嘌呤。[结果]产物6-苄氨基腺嘌呤及关键中间体结构经核磁确认正确。[结论]该合成路线具有反应时间短、收率高、成本低、适宜工业化生产等特点。
[Objective] The research aimed to study a new method of 6-benzylaminopurine synthesis. [Method] With acetic anhydride as the raw material, adenosine was acylated to generate 2 ’, 3’, 5’-trioxyacetyl adenosine. Under the action of catalyst, the purine bases and the glycosides Bond cleavage to generate acetyl adenine, and then in the phase transfer catalyst tetrabutylammonium fluoride role, and benzyl alcohol production of 6-benzyladenine adenine. [Result] The product 6-benzyladenine and the key intermediate structure were confirmed by NMR. [Conclusion] The synthetic route has the characteristics of short reaction time, high yield, low cost and suitable for industrialized production.