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NK 细胞(NKC)在机体免疫机制中所起的重要作用,已愈来愈为人们所重视。根据目前报导,可将免疫功能归纳为四方面:抗病毒感染、抗骨髓移植、参与免疫调节和抗肿瘤。其中NKC 的抗肿瘤作用更为人们所关注。本文就此问题综述如下:一、NK 细胞抗肿瘤的证据Minato 等报道,HeLa 细胞或BHK 细胞,即使少至100个,也能使全部裸鼠产生肿瘤;对于同样的瘤细胞,如被病毒(麻疹病毒、流感病毒等RNA 病毒)持续感染,即使细胞数高达2×10~7也不能使裸鼠发生肿瘤。实验发现:(1)被病毒持续感染的瘤细
The important role of NK cells (NKCs) in the immune mechanism of the body has drawn more and more attention. According to the current reports, immune function can be summarized into four aspects: antiviral infection, anti-bone marrow transplantation, involved in immune regulation and anti-tumor. Among them, the antitumor effect of NKC is more concerned by people. This article summarizes this issue as follows: First, the evidence of NK cell anti-tumor Minato and other reports, HeLa cells or BHK cells, even as few as 100 can also make all nude mice produce tumors; for the same tumor cells, such as the virus Viruses, influenza viruses and other RNA viruses) continue to infect, even if the number of cells up to 2 × 10 ~ 7 can not make tumors in nude mice. The experiment found that: (1) the virus sustained infection of the tumor fine