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目的评价替吉奥联合三维适形放疗治疗局部晚期胃癌的疗效及安全性。方法 68例局部晚期胃癌患者,随机分为替吉奥组(34例)与对照组(34例),对照组患者单纯采用三维适行放疗治疗,95%受照剂量(PTV)DT=45~50 Gy/25F,5次/周。替吉奥组在三维适形放疗基础上联合替吉奥口服治疗,30 mg/m2,2次/d,每天早、晚餐后,口服14 d,休息7 d,21 d为1个周期,共化疗2个周期。观察两组治疗效果。结果替吉奥组治疗有效率为67.6%明显高于对照组32.4%(P<0.05);胃肠道反应和骨髓抑制是最常见的不良反应,多为Ⅰ~Ⅱ级,且两组不良反应比较差异有统计学意义(P<0.05)。结论替吉奥联合三维适形放疗治疗局部晚期胃癌疗效肯定,不良反应可以耐受,值得临床上推广应用。
Objective To evaluate the efficacy and safety of TIGO combined with three-dimensional conformal radiotherapy in the treatment of locally advanced gastric cancer. Methods Sixty-eight patients with locally advanced gastric cancer were randomly divided into two groups: 34 for the treatment group and 34 for the control group. The patients in the control group were treated with appropriate three-dimensional radiotherapy and the PTV was 95% 50 Gy / 25F, 5 times / week. On the basis of three-dimensional conformal radiotherapy, Tegi group was treated with TIGO orally at a dose of 30 mg / m2 twice a day for 14 days, followed by a rest for 7 days and a 21-day rest for 1 cycle Chemotherapy 2 cycles. Observation of two groups treatment effect. Results The effective rate of treatment for the treatment group was 67.6%, significantly higher than that of the control group (32.4%, P <0.05). Gastrointestinal tract reaction and myelosuppression were the most common adverse reactions, mostly grade Ⅰ ~ Ⅱ, with adverse reactions The difference was statistically significant (P <0.05). Conclusion For the treatment of locally advanced gastric cancer with TIGO combined with three-dimensional conformal radiotherapy, the curative effect is definite, and the side effects can be tolerated. It is worth to be popularized clinically.