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临床及实验证据表明雌激素参与控制正常及肿瘤情况下肝细胞的增生。抗雌激素药它莫锡芬(Tamoxifen)可降低胞内及核内雌激素受体,抑制肝切除后肝再生,已被用于治疗肝腺癌。
Clinical and experimental evidence indicates that estrogen is involved in the control of hepatocyte proliferation under normal and tumor conditions. The anti-estrogen drug Tamoxifen reduces intracellular and intranuclear estrogen receptors, inhibits liver regeneration after hepatectomy, and has been used to treat hepatic adenocarcinoma.