目的针对益补颗粒剂的制备及其质量控制开展研究。方法采用水提醇沉的提取法,将处方药材制成颗粒剂,并采用高效液相色谱法测定制剂中补骨脂素含量。结果颗粒剂符合要求,其补骨脂素含量不低于3.591μg/g。结论该颗粒剂制备方法合理可行,其质量稳定,能满足药效研究的制剂应用要求。 Objective To study the preparation and quality control of Yibu granules. Methods The extraction method of water extraction and alcohol precipitation was used to formulate the prescription drug into granules. The content of psoralen in the preparation was determined by HPLC. Results The granules met the requirements and their psoralen content was not less than 3.591 μg/g. [Conclusion] The preparation method of the granules is reasonable and feasible. The quality of the granules is stable and can meet the application requirements of the pharmaceutical preparations.