鲎素抗菌肽是生物天然免疫的重要组成部分,具有广谱抗菌活性,对细菌、真菌、肿瘤细胞及一些病毒均具有强大的抑制作用(包括多药物耐受微生物),而且这种作用具有较好的选择性。本文主要介绍鲎素的种类和生物活性、鲎素的结构与功能关系、鲎素抗菌机理及鲎素基因工程表达制备方面的最新研究进展,并对鲎素临床应用面临的问题及对策作一简要综述。 Ribon antibacterial peptide is an important part of biological innate immunity, has broad-spectrum antibacterial activity, has a strong inhibitory effect on bacteria, fungi, tumor cells and some viruses (including multi-drug resistant microorganisms), and this effect has more Good choice. This article mainly introduces the types and biological activities of halogen, the structure and function of halogen, the antibacterial mechanism of halogen and the latest research progress in the preparation of gene for ribosomal gene expression, and briefly discusses the problems and countermeasures of its clinical application Summary.