内皮蛋白C受体 (EPCR)是近年发现的在炎症和抗凝过程中有重要意义的蛋白。它选择性表达在大血管的内皮细胞上 ,使PC活化效率提高 5倍。在炎症过程中它脱落为可溶性EPCR(sEPCR) ,能与中性粒细胞蛋白酶 - 3(PR3)结合。深入研究EPCR分子表达调控及相互作用的蛋白 ,对理解炎症、抗凝及细胞增殖修复间的关系具有重要意义 ,对活化PC(APC)治疗炎症的临床应用研究有指导作用。 Endothelial protein C receptor (EPCR) is a protein found in recent years that is important in the process of inflammation and anticoagulation. It is selectively expressed on the endothelial cells of the large vessels, increasing the efficiency of PC activation by a factor of five. It detaches into soluble EPCR (sEPCR) during inflammation and binds neutrophil proteinase-3 (PR3). In-depth study of the expression and regulation of EPCR molecules and their interaction proteins is of great significance for understanding the relationship between inflammation, anticoagulation and cell proliferation and repair, and plays a guiding role in the clinical application of activated PC (APC) in the treatment of inflammation.