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近年研究认为内耳疾病与高脂蛋白血症(HLP)有关。据欧美资料,不明原因的耳聋伴 HLP者约占20～30%,但日本较低,估计是饮食差异所致。HLP导致感音性聋的确切机制及组织病理改变尚不清楚。作者等使用100只体重350～400克的豚鼠,20只给标准饲料作对照,80只给高脂饲料(胆固醇2.5%,胆汁酸0.25%,牛脂7.5%)3个月后,通过脑干反应测定听阈;取心血进行20余项生化数据分析;采用新的组织化学方法探索内耳脂质代谢;以扫描、透射电镜检查耳蜗组织改变。3只重给标准饲料,3月后再行生化检查,来了解改变是否可逆。获下述结果:
Recent studies suggest that the inner ear disease is associated with hyperlipoproteinemia (HLP). According to European and American data, unexplained deafness with HLP accounted for about 20 to 30%, but Japan is low, it is estimated that the diet differences. The exact mechanism by which HLP causes sensorineural deafness and the histopathological changes are not yet known. The authors used 100 guinea pigs weighing 350-400 g, 20 control animals for standard diet, and 80 mice fed high-fat diet (cholesterol 2.5%, bile acid 0.25% and beef tallow 7.5%) for 3 months. The brainstem response Determination of hearing threshold; take blood for more than 20 biochemical data analysis; using new histochemical methods to explore the lipid metabolism of the inner ear; scanning and transmission electron microscopy examination cochlear tissue changes. 3 only to standard feed, biochemical tests after March to understand whether the change is reversible. Obtained the following result: