目的　探讨洛赛克、普瑞博思及洛赛克联合普瑞博思治疗返流性食管炎临床疗效。方法　对 12 0例反流性食管炎病人随机分 3组 ,分别口服洛赛克、普瑞博思、洛赛克和普瑞博思合用。结果　洛赛克组显效率及总有效率分别为 4 7 2 %及 85 4 %,普瑞博思组分别为 5 2 6 %及 89 4 %,洛赛克组联合普瑞博思组分别为83 3%及 95 8%。结论　联合用药效果理想。 Objective To investigate the clinical efficacy of Losec, Predock and Losec in combination with Pregabs in the treatment of reflux esophagitis. Methods A total of 120 patients with reflux esophagitis were randomly divided into 3 groups: oral administration of Losec, Pregabalus, Losec and Pregabalin. Results The effective rate and total effective rate of Losec group were 47.2% and 85.4%, respectively, with 52.6% and 89.4% respectively in the Pregabal group and 83.3% in the Losec group and Pregabalus group % And 95 8%. Conclusion The combination therapy is effective.