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目的研究奎尼丁对心室跨壁复极时间的影响。方法对5只犬用苯巴比妥麻醉后,开胸,用4个针状电极分别插入到左心室的基底部和心尖部,测量室壁激动恢复间期(ARI),静脉注射奎尼丁10mg/min后观察ARI的变化。结果窦性心律时心外膜、中层心肌和心内膜的ARI差异无统计学意义[分别为(261.0±31.5)ms、(263.0±27.9)ms和(264.7±26.1)ms,P>0.05]。奎尼丁对各层心肌的ARI均有延长作用,心外膜、中层心肌和心内膜的ARI分别延长了(65.8±17.3)ms、(71.3±13.7)ms和(64.3±16.7)ms(P>0.05)。结论奎尼丁对左心室的心外膜、中层心肌和心内膜复极的延长程度相似。
Objective To study the effect of quinidine on ventricular transmural repolarization time. Methods Five dogs were anesthetized with phenobarbital and then thoracotomy. Four acupuncture electrodes were inserted into the basal and apex of the left ventricle to measure the ventricular activation recovery interval (ARI). Intravenous injection of quinidine The change of ARI was observed after 10mg / min. Results There was no significant difference in ARI between epicardium, middle myocardium and endocardium in sinus rhythm [(261.0 ± 31.5) ms, (263.0 ± 27.9) ms and (264.7 ± 26.1) ms, respectively, P 0.05] . The mean ARI of epicardium, middle myocardium and endocardium were prolonged by (65.8 ± 17.3) ms, (71.3 ± 13.7) ms and (64.3 ± 16.7) ms ( P> 0.05). Conclusions The extension of quinidine to the left ventricular epicardium, middle myocardium and endocardial repolarization are similar.