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目的探讨节细胞性副神经节瘤的临床病理学特征、诊断及鉴别诊断,提高对该肿瘤的认识和诊断水平。方法分析2例节细胞性副神经节瘤的临床、组织病理学及免疫表型,并复习相关文献。结果镜下可见3种成分:上皮样细胞排列成巢或小梁状;梭形细胞呈束状或片状分布于上皮样细胞巢之间,似神经纤维瘤/神经鞘瘤;节细胞样细胞以单个或小团散在分布于以上两种细胞之间,分化成熟。3种细胞比例不一,均无明显的细胞学异型性。其中1例出现局部淋巴结转移。免疫组化:上皮样细胞CgA、Syn和NSE(+),梭形细胞vimentin和S-100(+),节细胞样细胞CgA、Syn和NSE(+)。结论节细胞性副神经节瘤是一种罕见的肿瘤,多发生于十二指肠,依据特征性的镜下表现并结合免疫组化可做出正确诊断。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of ganglion cell paraganglioma and improve the understanding and diagnosis of this tumor. Methods The clinical, histopathological and immunophenotypes of two cases of ganglionescent paraganglioma were analyzed and the related literature was reviewed. RESULTS: Three components were seen under the microscope: epithelioid cells arranged in nests or trabeculae; spindle cells were bundles or sheets distributed between epithelial-like cell nests, resembling neurofibromas/schwannomas; ganglion-like cells Spread in a single or small group between the two types of cells, differentiation mature. The proportions of the three kinds of cells were different, and there were no obvious cytological abnormalities. In one case, regional lymph node metastasis occurred. Immunohistochemistry: Epithelial-like cells CgA, Syn and NSE (+), spindle cells vimentin and S-100 (+), ganglion cell-like cells CgA, Syn and NSE (+). Conclusions Ganglion paraganglioma is a rare tumor that occurs in the duodenum. It can be diagnosed correctly based on the characteristic microscopic findings and immunohistochemistry.