目的对糖皮质激素两种给药途径治疗突发性耳聋的疗效进行观察比较。方法将61例突发性耳聋患者分为两组,局部给药组在采用药物治疗基础上加用地塞米松鼓室内注射,全身给药组在局部给药组药物治疗上加用地塞米松静脉滴注。结果局部给药组总有效率为77.42%,无不良反应;全身给药组总有效率为56.67%,3例有不良反应。两组有效率差异有统计学意义。结论地塞米松局部给药疗效优于全身给药,是替代全身给药的良好选择。 Objective To observe and compare the therapeutic effects of two routes of administration of glucocorticoids on sudden deafness. Methods Sixty-one patients with sudden deafness were divided into two groups. The local administration group was treated with dexamethasone intramuscular injection on the basis of drug treatment. The systemic administration group was treated with intravenous injection of dexamethasone Note. Results The total effective rate of the local administration group was 77.42%, no adverse reactions; the total effective rate of the systemic administration group was 56.67%, 3 patients had adverse reactions. The difference between the two groups was statistically significant. Conclusion The topical administration of dexamethasone is superior to systemic administration and is a good alternative to systemic administration.