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目的:探讨喉鳞状细胞癌(LSCC)原发灶与淋巴结转移灶在分子水平的差别及意义。方法:采用免疫组织化学SP法检测18例转移淋巴结阳性(N+)的LSCC患者,对其原发灶、转移灶及无转移淋巴结中PTEN和Survivin的表达进行检测;另取22例声带息肉(VCP)组织标本作为对照组。结果:无转移淋巴结患者的标本中均未见PTEN和Survivin的表达。LSCC、N+、VCP中PTEN阳性率分别为94.4%(17/18)、94.4%(17/18)和95.5%(21/22),3者阳性率比较,差异无统计学意义。N+的PTEN表达强度较LSCC为强,其表达强度差异有统计学意义(P<0.05);Survivin在VCP中未见阳性表达,在LSCC和N+中阳性率分别为55.6%(10/18)、50.0%(9/18),三者阳性率比较差异有统计学意义(P<0.01),但LSCC和N+中的阳性表达率和表达强度三组比较均无统计学意义(P<0.05)。结论:LSCC原发灶与淋巴结转移灶中分子水平的特点存在差异。
Objective: To investigate the difference and significance of the molecular level of primary tumor and lymph node metastasis in laryngeal squamous cell carcinoma (LSCC). Methods: Immunohistochemical SP method was used to detect the expression of PTEN and Survivin in 18 patients with metastatic lymph node positive (N +) LSCC. The expressions of PTEN and Survivin were detected in 22 patients with vocal cord polyp (VCP ) Tissue samples as control group. Results: The expression of PTEN and Survivin was not found in the specimens of patients without lymph node metastasis. The positive rates of PTEN in LSCC, N + and VCP were 94.4% (17/18), 94.4% (17/18) and 95.5% (21/22), respectively. There was no significant difference in the positive rates of PTEN among the three groups. The positive expression rate of PTEN in N + was higher than that in LSCC, and the expression intensity of the positive expression was statistically significant (P <0.05). The positive expression rate of Survivin in VCC was 55.6% (10/18) 50.0% (9/18) respectively. The positive rates of LSCC and N + in LSCC and N + were not significantly different between the three groups (P <0.05). Conclusion: The molecular characteristics of LSCC primary lymph node and lymph node metastasis are different.