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目的 为了解乙型肝炎患者重叠感染丙型肝炎病毒（ＨＣＶ） 的状况，并探讨乙型肝炎病毒（ＨＢＶ） 、ＨＣＶ 重叠感染时ＨＣＶ 对ＨＢＶ 复制的影响。方法 应用ＥＬＩＳＡ 法对７１２ 例乙型肝炎患者进行了血清抗－ ＨＣＶ 检测和乙型肝炎病毒标志检测。结果 ７１２ 例乙型肝炎患者血清抗－ ＨＣＶ阳性率为１４ ．４７ ％ ，其中重型肝炎患者血清抗－ ＨＣＶ 阳性率最高（４８ ．９８ ％ ） ，急性肝炎患者最低（３．２５ ％ ） 。在不同临床类型的乙型肝炎患者之间，血清抗－ ＨＣＶ 阳性率存在显著性差异（ Ｐ＜ ０ ．００１），显示病情越重，病程越长，血清抗－ ＨＣＶ 阳性率越高；在ＨＢＶ 和ＨＣＶ 重叠感染的患者中，血清ＨＢｓＡｇ、ＨＢｅＡｇ 和抗－ ＨＢｃＩｇＭ 阳性率低于乙型肝炎患者（ Ｐ＜ ０ ．００１ ，Ｐ＜ ０ ．００１ 和Ｐ＜０ ．０５） ，而血清抗－ ＨＢｅ 阳性率高于乙型肝炎患者（ Ｐ＜ ０ ．０１），均有显著的统计学意义。结论 乙型肝炎患者重叠感染ＨＣＶ 与病情加重和慢性化的形成有关，并使ＨＢＶ 的复制受到抑制。
Objective To investigate the status of Hepatitis C virus (HCV) infection in patients with Hepatitis B virus (HBV) infection and to explore the influence of HCV on HBV replication during Hepatitis B virus (HBV) and HCV infection. Methods Serum anti - HCV and hepatitis B virus were detected in 712 patients with hepatitis B by ELISA. Results The positive rate of anti-HCV in 712 hepatitis B patients was 14. 47%. Serum anti-HCV positive rate of patients with severe hepatitis was the highest (48.98%) and the lowest was 3.25% (acute hepatitis). There was a significant difference in the positive rate of anti-HCV between different clinical types of hepatitis B patients (P <0 .001), indicating that the more serious the disease, the longer the course of disease, the higher the positive rate of serum anti-HCV; The positive rates of serum HBsAg, HBeAg and anti - HBcIgM in patients with overlapping HCV infection were lower than those in patients with hepatitis B (P <0.001, P <0.001 and P <0.05), while the serum anti - HBe positive The rate was higher than that of hepatitis B patients (P <0.01), both of which had significant statistical significance. Conclusion Hepatitis C co-infection with HCV is associated with the aggravation and chronic formation of hepatitis B virus, and the replication of HBV is inhibited.