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目的观察边缘性锌缺乏对大鼠肥胖的影响。方法 SPF级成年雄性SD大鼠32只,随机分为4组,低锌组喂饲含6 mg/kg锌的边缘性锌缺乏饲料,中锌组喂饲含10 mg/kg锌的边缘性锌缺乏饲料,低锌对饲组和对照组喂饲正常锌含量的AIN-93M饲料。喂养6周后,处死动物。测血锌、血脂、血清瘦素含量,肝脏总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果低锌组大鼠第5周起血锌含量明显低于低锌对饲组和对照组(P<0.05),成功建立边缘性缺锌模型。第6周时,低锌组大鼠脂体比明显高于低锌对饲组和对照组(P<0.05);低锌组和中锌组大鼠肝脏MDA含量明显高于对照组(P<0.05);低锌组和中锌组大鼠肝脏TAOC、SOD水平明显低于对照组(P<0.05)。结论边缘性锌缺乏可增加肥胖发生的风险,缺锌组大鼠体内氧化应激升高可能是边缘性锌缺乏增加肥胖风险的主要原因。
Objective To observe the effects of borderline zinc deficiency on obesity in rats. Methods Thirty-two SD male Sprague-Dawley rats were randomly divided into 4 groups: the low zinc group fed marginal zinc deficient diet containing 6 mg / kg zinc; the medium zinc group fed marginal zinc containing 10 mg / kg zinc Lack of diet, low zinc diet group and control group fed normal zinc content of AIN-93M feed. After 6 weeks of feeding animals were sacrificed. Serum zinc, blood lipid, serum leptin, T-AOC, SOD and MDA were measured. Results In the low zinc group, the zinc level in the fifth week was significantly lower than that in the low zinc group (P <0.05), and the marginal zinc deficiency model was successfully established. At the 6th week, the lipid ratio in the low zinc group was significantly higher than that in the low zinc group (P <0.05); the liver MDA content in the low zinc group and the medium zinc group was significantly higher than that in the control group (P < 0.05). The liver TAOC and SOD in low zinc group and medium zinc group were significantly lower than those in control group (P <0.05). Conclusion Marginal zinc deficiency may increase the risk of obesity. Increased oxidative stress may be the main reason for the increased risk of obesity in borderline zinc deficiency rats.