线粒体融合蛋白2(Mfn2)在线粒体融合过程中发挥着重要作用，参与调节线粒体功能和形态学的改变。近年来研究发现，Mfn2在多种恶性肿瘤及其细胞株中具有抑癌作用，包括宫颈癌、肝细胞癌、胰腺癌、乳腺癌和膀胱癌等。Mfn2在恶性肿瘤组织中表达情况的差异，提示其可能在恶性肿瘤细胞增殖、凋亡、侵袭和转移过程中发挥重要作用。Mfn2作为一种肿瘤相关基因，为恶性肿瘤的基因治疗提供了新的思路。“,”Mitofusin 2 (Mfn2) plays an important role in the process of mitochondrial fusion, and is involved in regulating mitochondrial function and morphological changes. Studies have found that Mfn2 has a tumor suppressor effect in a variety of malignant tumors and their cell lines, including cervical cancer, hepatocellular cancer, pancreatic cancer, breast cancer, and bladder cancer. The difference in the expression of Mfn2 in malignant tumor tissues suggests that Mfn2 may play an important role in the proliferation, apoptosis, invasion and migration of malignant tumor cells. As a cancer-related gene, Mfn2 provides new ideas for gene therapy of malignant tumors.