目的探讨柔红霉素在治疗小儿急性白血病中产生的心脏毒性。方法总结1990年1月至2007年5月在中国医科大学附属第一医院就诊的92例接受柔红霉素治疗的急性白血病患儿临床资料,对其中12例发生心脏毒性的患儿按药物累积量进行分组分析。结果92例患儿中有12例出现心脏毒性,年龄越小,累积量越大,心脏毒性发生率越高。结论治疗白血病患儿时应严格控制柔红霉素累积剂量,定期对心脏进行相关检查,长期随访以便及早发现心脏损伤。 Objective To investigate the cardiotoxicity of daunorubicin in the treatment of pediatric acute leukemia. Methods From January 1990 to May 2007, 92 cases of children with acute leukemia treated with daunomycin were enrolled in the First Affiliated Hospital of China Medical University. The clinical data of 12 children with cardiotoxicity Quantitative group analysis. Results Twelve of 92 children had cardiotoxicity. The younger the age, the higher the cumulative amount was and the higher the incidence of cardiotoxicity was. Conclusions The accumulated dose of daunorubicin should be strictly controlled in children with leukemia. The heart should be checked regularly and be followed up for a long time to find the heart damage.