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原发性胆道恶性肿瘤,发病隐匿,加之恶性程度高,浸润和转移快,一经临床诊断多为中晚期,所以临床上病人手术切除率低,预后差,目前有关胆道肿瘤相关分子生物学研究很多,但尚未取得实质性进展。尾型同源盒转录因子2(caudal-typehomeoboxgene transcription factor 2,CDX2)对生物的发育和细胞的分化具有重要作用,尤其在肠上皮细胞正常分化和增殖过程中起关键作用,研究表明CDX2与消化道肿瘤发生发展有一定相关性。本文就国内外所做相关研究作一综述,旨在进一步探讨CDX2与原发性胆道恶性肿瘤的相关性,为原发性胆道恶性肿瘤的诊治方案的选择和预后的评估提供参考。
Primary biliary malignancies, the incidence of occult, combined with a high degree of malignancy, infiltration and metastasis, once the clinical diagnosis of mostly in the advanced stage, so the clinical operation of patients with low resection rate, the prognosis is poor, the current research on molecular biology of biliary tract tumors , But no substantive progress has been made yet. The caudal-type homeobox transcription factor 2 (CDX2) plays an important role in the development and differentiation of cells, especially in the normal differentiation and proliferation of intestinal epithelial cells. Studies have shown that CDX2 and digestion Road tumor development has some relevance. This review summarizes the relevant researches done both at home and abroad to further explore the relationship between CDX2 and primary biliary malignancies and to provide references for the selection and prognosis evaluation of primary biliary malignancies.