甾体类激素在骨代谢中起着重要作用,绝经妇女补充雌激素可以预防及治疗绝经后骨质疏松,但其具体作用机制仍不是很清楚。成骨细胞在骨代谢调节中起着重要作用,它通过分泌释放细胞因子来调节破骨细胞的数量和作用。既往观点认为,在骨形成过程中由成骨细胞分泌骨基质,新生成的骨基质因钙盐沉着而矿化为骨。随着骨基质的增加,成骨细胞的功能降低,并逐渐被其分泌 Steroid hormones play an important role in bone metabolism, postmenopausal women with estrogen can prevent and treat postmenopausal osteoporosis, but its specific mechanism of action is still not very clear. Osteoblasts play an important role in the regulation of bone metabolism, which regulate the number and function of osteoclasts by secreting and releasing cytokines. In the past, it was thought that the bone matrix was secreted by osteoblasts during the process of bone formation, and the newly formed bone matrix was mineralized into bone due to calcium sedation. As the bone matrix increases, osteoblasts function less and are gradually secreted