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目的探讨正常人和糖尿病患者泪糖浓度和血糖浓度的相关性。方法 2型糖尿病(T2DM)患者75例85只眼(A组)和正常对照组28例28只眼(B组),以微量血糖仪测定两组空腹血糖,随即以微量采血管采集非刺激性泪液20μl并以高效液相色谱质谱联用法(HPLC-MS)测定泪糖。结果 A组泪糖明显高于B组[(0.460±0.204)mmol/L vs.(0.081±0.027)mmol/L](P<0.01)。A组泪糖与血糖呈直线正相关(r=0.870,P<0.01);B组泪糖与血糖无直线相关(r=0.229,P>0.05)。结论在糖尿病患者中,泪糖浓度可以作为一个反映血糖浓度的良好指标。
Objective To investigate the relationship between the concentration of tear sugar and blood glucose in normal subjects and diabetic patients. Methods Totally 85 eyes (group A) of 75 patients with type 2 diabetes mellitus (T2DM) and 28 eyes (28 eyes) of normal control group (B group), fasting plasma glucose Tear tear 20μl and high performance liquid chromatography mass spectrometry (HPLC-MS) tear sugar. Results Tear sugar in group A was significantly higher than that in group B [(0.460 ± 0.204) mmol / L vs. (0.081 ± 0.027) mmol / L] (P <0.01). There was a linear positive correlation between tear sugar and blood sugar in group A (r = 0.870, P <0.01). There was no linear correlation between tear sugar and blood sugar in group B (r = 0.229, P> 0.05). Conclusion Tear sugar concentration can be used as a good indicator of blood glucose concentration in diabetic patients.