转化生长因子 β(transforminggrowthfactors β ,TGF β )是一类具有多种生物学活性的细胞因子 ,参与调节细胞的增殖、分化、发育和凋亡等多种生命活动。本文综述了近年来TGF β信号转导途径的研究进展 ,并着重探讨了TGF β信号转导途径中各组成部分 ,包括配体、受体及Smads蛋白等异常与肿瘤发生、发展、浸润及转移之间的关系 Transforming growth factor β (TGFβ) is a class of cytokines with multiple biological activities and is involved in the regulation of cell proliferation, differentiation, development and apoptosis and other life activities. This article reviews the recent advances in TGFβ signal transduction pathways and focuses on the analysis of the components of TGFβ signal transduction pathways, including abnormalities of ligands, receptors, and Smads, as well as tumorigenesis, development, infiltration, and metastasis. The relationship between