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目的:探究优甲乐结合温阳益气活血法及中医辅助治疗原发性甲状腺功能减退症的临床价值。方法:选取医院2013年5月—2016年5月收治的182例原发性甲状腺功能减退症患者作为研究对象,采取随机数字表法将患者分为观察组(91例)和对照组(91例),对照组所有患者均予以优甲乐治疗,观察组患者在对照组治疗基础上采取温阳益气活血法及中医辅助治疗,对比两组疗效、治疗前后中医证候积分及患者血液流变学指标、治疗后两组患者甲状腺激素水平、血脂测定情况及血清甲状腺相关抗体情况、不良反应及治疗满意度。结果:观察组患者治疗总有效率高达100.00%,显著高于对照组92.31%,P<0.05;两组治疗前中医证候积分相当,P>0.05;治疗后观察组积分为(6.32±3.26)分,显著优于对照组积分(9.56±4.26)分,P<0.05;观察组患者治疗后甲状腺激素水平、血脂测定情况及血清甲状腺相关抗体情况均优于对照组,P<0.05;治疗后两组患者全血黏度与血浆黏度均降低,P<0.05,两组患者全血黏度与血浆黏度无差异,P>0.05;两组观察组总不良反应率为1.10%,与对照组相当2.20%,P>0.05,治疗满意率为98.90%,显著高于对对照组90.11%,P<0.05。结论:优甲乐结合温阳益气活血法及中医辅助治疗原发性甲状腺功能减退症具有极高临床价值,治疗效果佳,患者甲状腺功能恢复好,不良反应少,安全性高,患者高度认可,可于临床广泛应用。
Objective: To explore the clinical value of Euthyrox in combination with warming yang qi and activating blood circulation and Chinese medicine auxiliary treatment of primary hypothyroidism. Methods: A total of 182 patients with primary hypothyroidism admitted to our hospital from May 2013 to May 2016 were selected as study subjects. Patients were divided into observation group (91 cases) and control group (91 cases) by random number table ). All patients in the control group were treated with Euthyrox. The patients in the observation group were treated with warming Yang, invigorating Qi and activating blood circulation and Chinese medicine adjuvant therapy on the basis of the control group. The curative effect of TCM, the TCM syndrome score before and after treatment and the hemorheological indexes After treatment, thyroid hormone levels, serum lipids and serum thyroid-related antibodies, adverse reactions and treatment satisfaction were compared between the two groups. Results: The total effective rate of observation group was 100.00%, which was significantly higher than that of control group (92.31%, P <0.05). The scores of TCM syndromes before treatment were similar in both groups (P> 0.05), and the scores of observation group were (6.32 ± 3.26) (9.56 ± 4.26) points, P <0.05. The levels of thyroid hormone, serum lipids and serum thyroid-related antibodies in the observation group were better than those in the control group (P <0.05). After treatment, The whole blood viscosity and plasma viscosity of the two groups were decreased, P <0.05. There was no difference between the two groups in the whole blood viscosity and the plasma viscosity (P> 0.05). The total adverse reaction rate was 1.10% in the observation group and 2.20% in the control group, P> 0.05. The satisfaction rate of treatment was 98.90%, which was significantly higher than that of the control group (90.11%, P <0.05). Conclusion: Euthyrox synergistic combination of warming Yang and invigorating qi and activating blood circulation and traditional Chinese medicine adjuvant therapy for primary hypothyroidism has high clinical value, good curative effect, good recovery of thyroid function, few adverse reactions, high safety and highly recognized by patients Widely used in clinical.