虽然每两个白血病人或实体肿瘤病人中就有一人的淋巴细胞能识别或经诱导而识别自体肿瘤细胞,但很难证明人体淋巴细胞对自体肿瘤细胞的识别是由肿瘤特异性抗原(TSA)所介导,此外,人体肿瘤细胞具有显著的免疫异质性.所以非抗体依赖性免疫监视正日益受到重视.非抗体依赖性免疫监视由细胞毒巨噬细胞(Mφ)、自然杀伤细胞(NK)和自然杀伤样细胞(NK like)毒T细胞执行. Although one out of two leukemia human or solid tumor patients can recognize or induce autologous tumor cells, it is difficult to prove that human lymphocytes recognize autologous tumor cells by tumor-specific antigen (TSA). Mediated, in addition, human tumor cells have significant immunological heterogeneity. Therefore, non-antibody dependent immune surveillance is gaining more and more attention. Non-antibody dependent immune surveillance consists of cytotoxic macrophages (Mφ), natural killer cells (NK ) and natural killer-like cells (NK-like) toxic T cells perform.