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目的观察贝那普利联合红花黄色素对慢性肾小球肾炎的疗效。方法将2010年1月-2012年1月我科收治的92例肾功能正常的慢性肾小球肾炎患者列为研究对象,按照随机数字表法分为对照组(贝那普利组)和治疗组(贝那普利+红花黄色素组),每组46例。在治疗前及终点分别检测2组患者24h尿蛋白定量、血压、血肌酐等实验室指标,应用统计学方法分析比较治疗效果。结果 2个疗程后,治疗组完全缓解率(50.0%)明显高于对照组(P<0.05);治疗组患者24h尿蛋白、尿素氮、血肌酐均低于对照组(P<0.05)。结论贝那普利联合红花黄色素能有效地降低慢性肾小球肾炎蛋白尿,具有较好疗效。
Objective To observe the curative effect of benazepril combined with safflower yellow on chronic glomerulonephritis. Methods A total of 92 patients with chronic glomerulonephritis with normal renal function were enrolled in our department from January 2010 to January 2012. The patients were divided into control group (benazepril group) and treatment according to random number table Group (benazepril + safflower yellow group), 46 cases in each group. The urinary protein excretion, blood pressure and serum creatinine were measured in two groups before and at the end of treatment, respectively. Laboratory statistic was used to analyze and compare the therapeutic effect. Results After 2 courses of treatment, the complete remission rate (50.0%) in the treatment group was significantly higher than that in the control group (P <0.05). The urinary protein, urea nitrogen and serum creatinine in the treatment group were lower than those in the control group (P <0.05). Conclusion benazepril combined with safflower yellow can effectively reduce the proteinuria of chronic glomerulonephritis, has a good effect.