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目的观察蛇岛牌精制蝮蛇抗栓酶对Ⅱ型糖尿病并脑梗死的疗效。方法各选择１３５例Ⅱ型糖尿病并脑梗死患者为治疗组和对照组，两组患者既往史和伴发病积分无显著差异。两组均在起病后６～７２ｈ开始治疗。治疗组：用精制蝮蛇抗栓酶首剂３．０ＩＵ，每日１次，连续使用３次，隔日改为１．０ＩＵ治疗１０次，每疗程为１４天。对照组：低分子右旋糖酐５００ｍｌ，每日１次，共１４次。治疗中行凝血指标测定、颅ＣＴ、血流变检查及副作用观察，然后进行统计学处理。结果治疗后，神经功能评分，血流变有显著差异，治疗组疗效优于对照组，无副作用。且对糖尿病并发症有很好的治疗作用，但与无糖尿病脑梗死者相比疗效略差。结论精制蝮蛇抗栓酶治疗糖尿病并脑梗死优于低分子右旋糖酐对照组，对肾脏无损害。
Objective To observe the effect of snake island brand refined viper antithrombin on type Ⅱ diabetes mellitus and cerebral infarction. Methods 135 cases of type Ⅱ diabetes mellitus and cerebral infarction were selected as the treatment group and the control group. There was no significant difference between the two groups in the past history and the associated disease score. Both groups started treatment after 6 ~ 72h after onset. Treatment group: the purified viper antithrombotic first dose of 3.0IU, 1 times a day for 3 consecutive use, the next day to 1.0IU treatment 10 times, each course of 14 days. Control group: low molecular weight dextran 500ml, once daily for 14 times. Treatment of blood coagulation indicators, cranial CT, blood rheology examination and side effects observed, and then for statistical analysis. Results After treatment, neurological scores, hemorrheology were significantly different, the treatment group than the control group, no side effects. And the complications of diabetes have a good therapeutic effect, but compared with non-diabetic patients with cerebral infarction slightly worse. Conclusion The purified viper snake antithrombin enzyme treatment of diabetes mellitus and cerebral infarction better than low molecular weight dextran control group, no damage to the kidneys.