本文报道用一次大剂量~(131)碘治疗甲状腺自主功能性结节22例疗效观察,结果痊愈20例,明显好转2例.随访6～11年,尚未发现近期不良反应、复发及并发甲低病例,亦未发现白细胞减少、再生障碍性贫血、白血病及肿瘤患者.本组有12例来自边远山区,有长期食用碘盐历史,其发病是否与摄碘过多有关,尚需进一步调查研究. This article reports the use of a large dose of 131I treatment of thyroid autonomic functional nodules in 22 cases, the results were cured in 20 cases, significantly improved in 2. Follow-up of 6 to 11 years, no adverse reactions have been found recently, recurrence and concurrent hypothyroidism Cases, nor found leukopenia, aplastic anemia, leukemia and cancer patients.There are 12 cases from this group of remote mountainous areas, the history of long-term consumption of iodized salt, the incidence is associated with excessive intake of iodine, the need for further investigation.