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目的分析沙眼衣原体(CT)、解脲支原体(UU)、人型支原体(MH)在输卵管性不孕症患者生殖道的感染状况,为合理用药提供参考。方法选择台州市立医院收治的输卵管性不孕患者93例作为不孕组,同时选取健康女性50例作为对照组,所有研究对象均进行CT、UU及MH检测,并进行分析。结果不孕组CT、UU、MH、CT+UU、UU+MH、CT+UU+MH及总感染率均高于对照组,差异均有统计学意义(P均<0.01)。多因素Logistic回归分析显示输卵管性不孕与CT、UU、CT+UU、UU+MH感染均密切相关(CT:OR=3.371,P=0.045;UU:OR=2.795,P=0.021;CT+UU:OR=7.538,P=0.016;UU+MH:OR=4.816,P=0.036)。其中CT+UU与输卵管性不孕的联系最密切。支原体药敏实验显示,UU对强力霉素、克拉霉素、交沙霉素、罗红霉素敏感率较高(敏感性均为91.67%);MH对强力霉素、交沙霉素和壮观霉素较敏感(敏感性为87.50%、87.50%和75.00%);UU+MH对交沙霉素较敏感(敏感性为72.72%)。结论输卵管性不孕患者应重视病原体检测,根据病原体的药敏结果选择适当药物进行治疗。
Objective To analyze the infection status of genital tract in patients with tubal infertility by using CT, UU and MH, and to provide a reference for rational drug use. Methods 93 cases of tubal infertility patients admitted to Taizhou Municipal Hospital were selected as the infertility group and 50 healthy women were selected as the control group. All subjects were examined by CT, UU and MH, and analyzed. Results The infective group CT, UU, MH, CT + UU, UU + MH, CT + UU + MH and total infection rate were higher than the control group, the difference was statistically significant (P all <0.01). Multivariate Logistic regression analysis showed that tubal infertility was closely related to CT, UU, CT + UU and UU + MH infection (CT: OR = 3.371, P = 0.045; UU: OR = 2.795, P = 0.021; : OR = 7.538, P = 0.016; UU + MH: OR = 4.816, P = 0.036). CT + UU which is most closely related to tubal infertility. Mycoplasma sensitivity test showed that UU had a higher sensitivity to doxycycline, clarithromycin, jasamycin, and roxithromycin (all of them were 91.67% sensitive); MH had no effect on doxycycline, josamycin and spectacular (Sensitivity 87.50%, 87.50% and 75.00%). UU + MH was more sensitive to jasamycin (sensitivity 72.72%). Conclusion Tubal infertility patients should pay attention to the detection of pathogens, according to the results of drug susceptibility of pathogens choose the appropriate drug for treatment.