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癌症是继心血管疾病后的人类第二大杀手。源于植物的药物在癌症临床化疗中起着重要作用。近年来,随着肿瘤细胞中多个生物靶点的成功识别,可攻击这些靶点的若干有机小分子药物相继上市,其中喹唑啉类药物已成为临床上最常见的抗肿瘤化疗药物类别之一。本文综述了自2000年以来与喹唑啉化学结构相似的喹啉和萘啶类衍生物抗肿瘤活性及其构-效关系的研究进展。
Cancer is the second largest killer of humans after cardiovascular disease. Plant-derived drugs play an important role in clinical cancer chemotherapy. In recent years, with the successful identification of multiple biological targets in tumor cells, several organic small molecule drugs that can attack these targets have been listed one after another, and the quinazoline drugs have become the most common clinical anti-tumor chemotherapeutic drug category one. This review summarizes the antitumor activity and the structure-activity relationship of quinoline and naphthyridine derivatives with similar chemical structures to quinazoline since 2000.