中药芫花的生药学研究

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“芫花”自古用为逐水药,近年来常被选用作为治疗晚期血吸虫病消除腹水症的药物之一.作者首先就目前国内14省39市(县)52处药材供销部门直接、间接所获得以“芫花”为名的商品材料,参照原植物进行鉴定,计得二种不同的植物来源,即 Daphne genkwaSieb.et Zucc.与 Wikstroemia chamaedaphne Meisn.二种(均同为瑞香科植物),认为商品芫花确有异物同名的问题存在.针对以上情况,作者进行了本草学的考证.结论如下:(1)古本草中对芫花形态较早有完整描述而可借以推定品种的,当为韩保昇(蜀本草)的记载,先前吴普(吴氏本草)、陶氏(名医别录)之所言,虽较简略,但亦十分重要.反复考证,认为自吴普以来的本草正品芫花应为 Daphne genkwa Sieb.et Zucc.亦即‘证类本草’之“滁州芫花”.(2)‘证类本草’之“绵州芫花”其图外表与“滁州芫花”虽有出入,但多方面证明,实际上与“滁州芫花”为同种.(3)‘证类本草’之“绛州芫花”即‘图经’之“黄芫花”,其原植物应为 Wikstroemia cha-maedaphne Meisn.日本学者中尾万三误以为是 Wikstroemia trichotoma Mak.应予改正。(4)通过古本草的考证,认为 Dephne genkwa Sieb.et Zucc.与 Wikstroemia chamae-daphne Meisn.二者在“逐水”功用上相似,可以互相代用,但其它疗效未尽相同.为了保证临床用药的质量,弄清芫花品种,建议将后者按宋代苏颂‘图经’“黄芫花”之名而予以复名,俾与正品芫花相区别.(5)黄芫花商品夹杂物(叶、花轴、果实等)太多,通常为30—50%,与古人药用花蕾之旨不合,对预期的疗效可能有一定的影响,夹杂物许可存在的量,在商品标准规格制订以前似可按正品芫花现行情况作参考(一般应在10%以下). “Suihua” has been used as a water-repellent drug since ancient times. In recent years, it has often been used as one of the drugs for the treatment of ascites elimination in the treatment of advanced schistosomiasis. The author firstly directly and indirectly examined 52 medicinal materials supply and marketing departments of 39 cities (counties) in 14 provinces. Obtained commercial materials under the name of “Jinhua”, identified with reference to the original plant, and obtained two different plant sources, namely, Daphne genkwa Sieb.et Zucc. and Wikstroemia chamaedaphne Meisn. (both are plants of the family Rutaceae). The author believes that the existence of foreign objects with the same name exists in the product. In view of the above situation, the author conducts the textual research of Herbology. The conclusions are as follows: (1) In the ancient herbal plants, the complete description of the silk flower shape can be used earlier to determine the species. The record of Han Baosheng (Sakamoto Materia Medica), formerly known as Wu Pu (Wu’s Materia Medica) and Dow (Doctor’s Note), is relatively simple, but it is also very important. It has been repeatedly researched and considered that since the beginning of Wu Pu’s herbal medicine It should be Daphne genkwa Sieb.et Zucc. It is the “Chenzhou Suihua” of “Essentials Materia Medica”. (2) The “Mianzhou Suihua” of “Evidence Materia Medica” has its own appearance and appearance. , but proved in many aspects, in fact, with “Chuzhou wolfberry flower” The same species. (3) ’Everything of Materia Medica’, ’Yangzhou Luhua’, ’Yuanhua’ of ’Tujing’, the original plant should be Wikstroemia cha-maedaphne Meisn. The Japanese scholar mistakenly thinks that it is Wikstroemia trichotoma Mak. Should be corrected. (4) According to the research of ancient herbs, it is believed that both Dephne genkwa Sieb.et Zucc. and Wikstroemia chamae-daphne Meisn. are similar in terms of “water-by-water” function, and they can be substituted for each other, but other effects are not the same. To ensure clinical medication The quality of the cultivars is known to clarify the varieties of glutinous flowers. It is recommended that the latter be renamed according to the name of Su Song ’Tu Jing’ and ’Huang Hua Hua’ in the Song Dynasty. Differences between wolfberry and authentic hua flowers. (5) Yellow yew flowers, commodity inclusions (leaf, flower) Axis, fruit, etc.) is too much, usually 30-50%, which is different from the purpose of ancient medicinal buds, may have a certain impact on the expected curative effect, and the amount of permitted inclusions may be pressed before the formulation of commodity standards. Authentic flowers are used for reference (usually less than 10%).
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