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目的研究汉族健康志愿者单剂量静脉滴注盐酸头孢吡肟后的药物代谢动力学。方法汉族健康志愿者10名,男女各半,单剂量静脉滴注盐酸头孢吡肟1.0 g,采用HPLC法测定血浆中头孢吡肟的含量,用DAS软件进行数据处理。结果健康志愿者单剂量静脉滴注1.0 g盐酸头孢吡肟后的药物动力学参数:mρax为(68.75±10.41)mg.L-1、t1/2β为(1.97±0.20)h、AUC0-10.5 h为(136.89±23.02)mg.h.L-1、AUC0-∞为(139.69±23.78)mg.h.L-1。结论汉族健康志愿者单剂量静脉滴注盐酸头孢吡肟的体内药物动力学过程符合二室模型,不同性别受试者药物动力学参数的差异无统计学意义。
Objective To study the pharmacokinetics of single-dose intravenous cefepime in healthy Han volunteers. Methods A total of 10 healthy Han volunteers were enrolled in this study. One male and half female were divided into two groups. Single dose of cefepime hydrochloride 1.0 g was injected. The content of cefepime in plasma was determined by HPLC, and the data was processed by DAS software. Results The pharmacokinetic parameters of 1.0 g cefepime hydrochloride in single-dose intravenous drip of healthy volunteers were: mρax (68.75 ± 10.41) mg.L-1, t1 / 2β (1.97 ± 0.20) h, AUC0-10.5 h (136.89 ± 23.02) mg.hL-1, and the AUC0-∞ was (139.69 ± 23.78) mg.hL-1. Conclusion The pharmacokinetics of single-dose intravenous infusion of cefepime in healthy volunteers in Han nationality comply with the two-compartment model. There is no significant difference in pharmacokinetic parameters among different sex subjects.