论文部分内容阅读
应用烟酸可降低冠心病的死亡率和心肌梗塞(MI)恢复后的总死亡率,但由于明显的副作用,而使临床使用受到限制。本研究旨在评价较低剂量的烟酸对维持高密度脂蛋白(HDL)胆固醇的作用。将长期医学监护、心血管病病情稳定的55例患者列为烟酸治疗组,另外17例不愿接受烟酸治疗者作为对照组。空腹14h 后测定总胆固醇、HDL 胆固醇和三酸甘油脂浓度。研究期间患者尽量保持原来治疗。治疗组病人第1周烟酸剂量为250mg/d,以后每周日剂量增加250mg,至第4周达到最大剂量为1g/d。对照组病人分别于研究开始、6个月后检查血脂,治疗
The use of nicotinic acid reduces coronary heart disease mortality and total mortality after myocardial infarction (MI) recovery, but clinical use is limited by significant side effects. The aim of this study was to evaluate the effect of lower doses of niacin on the maintenance of high-density lipoprotein (HDL) cholesterol. A total of 55 patients with long-term medical care and stable cardiovascular diseases were enrolled in the niacin treatment group. Another 17 patients were reluctant to receive nicotinic acid as a control group. Total cholesterol, HDL cholesterol and triglyceride concentrations were measured 14 h after fasting. During the study patients try to keep the original treatment. Patients in the treatment group had a niacin dose of 250 mg / d in the first week, and a daily dose of 250 mg after the next week, reaching a maximum dose of 1 g / d in the fourth week. The control group of patients at the beginning of the study, 6 months after the inspection of blood lipids, treatment