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36例早产儿随机分为两组,小剂量A组20例,高剂量B组16例,日龄2～10天,平均5.56±3.03天。静脉输糖速率分别为8mg·kg~(-1)/min及12mg·kg~(-1)/min,观察空腹时、补糖3h及停止补糖后3h的血糖及胰岛素水平。结果表明高剂量B组婴儿血糖值显著高于A组,高血糖发生率高达100％。两组各时项血清胰岛素值比较无显著性差异。提示早产儿胰岛素β细胞对较高剂量的葡萄糖输入缺乏合适的应答反应,为避免高血糖,早产儿静脉补糖时需控制补糖剂量。
Thirty-six premature infants were randomly divided into two groups: 20 cases in low-dose group A and 16 cases in high-dose group B, with a mean age of 5.56 ± 3.03 days between 2 and 10 days. Intravenous glucose infusion rates were 8 mg · kg -1 / min and 12 mg · kg -1 / min, respectively. The fasting blood glucose and insulin levels were observed at 3h after sugar replacement and 3h after sugar replacement. The results showed that high-dose group B infants blood glucose value was significantly higher than the A group, the incidence of hyperglycemia as high as 100%. There was no significant difference in serum insulin between two groups at each time point. Tip premature insulin β-cell lack of appropriate response to higher doses of glucose input response, in order to avoid hyperglycemia, premature infants need to control the amount of sugar in the intravenous infusion of sugar.