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目的:探讨血浆肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及血清、尿液中胰蛋白酶原激活肽(TAP)与急性胰腺炎(AP)严重程度的相关性,为早期预测重症胰腺炎提供有临床价值的指标。方法:61例AP患者分为重症AP(30例)和轻症AP(38例)两组,另选择30例健康正常人作为对照组,比较各组血浆TNF-α、IL-6及血清、尿液TAP水平。结果:入院时AP患者血浆TNF-α、IL-6及血清、尿液TAP水平均明显高于正常对照组(P均<0.01);重症AP组患者TNF-α、IL-6及血清、尿液TAP水平均明显高于轻症AP组(P均<0.05)。结论:TNF-α、IL-6及血清、尿液TAP水平变化与AP病情变化密切相关,病程早期检测TNF-α、IL-6及血清、尿液TAP水平有助于重症急性胰腺炎的预测。
Objective: To investigate the correlation between plasma TNF-α, IL-6, serum and urine TAP and the severity of acute pancreatitis (AP) in patients with acute pancreatitis (AP) It can provide clinical value for the early prediction of severe pancreatitis. Methods: Sixty-one patients with AP were divided into two groups: severe AP (30 cases) and mild AP (38 cases), and another 30 healthy controls were selected as control group. Plasma levels of TNF-α, IL- Urine TAP levels. Results: At admission, the levels of plasma TNF-α, IL-6, serum and urine TAP in AP patients were significantly higher than those in normal controls (all P <0.01). TNF-α, IL-6, TAP levels were significantly higher in patients with mild AP (all P <0.05). CONCLUSION: The changes of TNF-α, IL-6, serum and urine TAP levels are closely related to the changes of AP disease. Early detection of TNF-α, IL-6 and serum and urine TAP level may contribute to the prediction of severe acute pancreatitis .